Creatine is one of the most researched supplements, but what does it actually do for you?
If you are exploring the benefits of creatine, you are probably trying to select the best product, or maybe you’re wondering if it’s the missing piece in your supplement regimen. You’ve most likely done your research, and like many individuals focused on enhancing performance, you’re ready to move past the hype and get to the data.
This article cuts through the noise to give you the science-backed answers. You will learn what creatine does, the benefits of creatine, and how it compares to C60.
Creatine 101 — Understanding the Basics
Creatine is a naturally occurring compound found in muscle cells. It is synthesized in the body from three amino acids, which are arginine, glycine, and methionine. Creatine is also found in some of the foods we eat, such as cow’s milk, red meat, fish, and seafood.
In our bodies, creatine is stored in muscles as phosphocreatine and is used to produce ATP (adenosine triphosphate). ATP is the primary source of energy used by cells, particularly during short bursts of intense activity.1
There are times when the body is in need of a quick energy store, as during high-intensity physical activity, such as weightlifting or sprinting, ATP is rapidly depleted, and the body taps into its creatine stores for that boost.1,2
The Benefits of Creatine
-
Enhanced Athletic Performance
Research has shown that creatine supplementation improves performance in activities that require short bursts of energy, such as sprinting, weightlifting, and high-intensity interval training (HIIT). It enhances muscle power output and endurance, enabling athletes to perform more reps and tolerate high volumes of training.1 If you’re wondering how, well, creatine supplementation may be related to tapping into the glycogen swiftly stored in muscle, thereby supporting an instant release of glucose.1,3,4
2. Increased Muscle Mass
Creatine is known to increase muscle mass over time. It helps to draw water into muscle cells, increasing cell volume. This increased cell volume can also trigger muscle protein synthesis, leading to hypertrophy (muscle growth).1,4
3. Improved Cognitive Function
Emerging research suggests that creatine may help to support cognitive benefits, particularly in situations involving mental fatigue or sleep deprivation. Since the brain uses ATP for energy, supplementing with creatine may help improve mental clarity and decision-making abilities.1
4. Neuroprotective Effects
In addition to its cognitive benefits, creatine may also play a role in protecting the brain from neurodegenerative diseases. Some studies suggest that creatine may help to support to reduce the risk or slow the progression of neurodegenerative conditions like muscular dystrophy, Parkinson’s disease, as well as in aging and brain health.1
5. Recovery and Injury Prevention
Creatine has been shown to assist with muscle recovery by reducing muscle damage and inflammation following intense exercise. Some studies have demonstrated that creatine supplementation reduced markers of muscle damage and soreness after high-intensity resistance training.1,6 By supporting faster recovery, creatine allows for more frequent training sessions and can help athletes train harder and more effectively in the long run.
Types of Creatine
There are several forms of creatine available on the market, each with unique characteristics. The most common types include:
- Creatine monohydrate – the most commonly used form and the one most studied.1,3
- Creatine Hydrochloride (HCl)
- Micronized Creatine
- Creatine Ethyl Ester (CEE)
- Buffered Creatine
- Creatine Magnesium Chelate
It is best to discuss with your healthcare provider (HCP) the different types of creatine and how they compare in terms of their benefits, as well as whether you are a candidate for using creatine.
Thinking About Taking Creatine?
Creatine supplementation is beneficial for many individuals, however, to reiterate, it is imperative that you speak with your HCP before starting creatine or any dietary supplement. While creatine is generally safe for most individuals, those with pre-existing kidney conditions or any medical concerns should consult with a healthcare professional before supplementation.
- Athletes or others who are active in intense sports or activities like sprinting, basketball, hockey, football, and weightlifting may experience improved performance, muscle mass, and recovery.1,4,6
- Older adults: As we age, muscle mass and strength naturally decline. Creatine helps preserve muscle mass and improve cognitive function in older individuals, who naturally lose muscle with age.1,2,3
- Vegetarians and vegans: Since creatine is naturally found in animal products, vegetarians and vegans may have lower baseline creatine levels secondary to consuming the majority of plant-based foods.
Prioritize: A Safe and Clean Creatine Supplement
If you are considering taking a dietary supplement, it is essential to investigate not only what is listed on the label, but also how the supplement’s ingredients have been sourced, manufactured, and tested for safety and purity. Here are a few things to look for when choosing a creatine supplement.5
- Purity. Choose creatine monohydrate as your base form. Look for products that contain only creatine monohydrate, without unnecessary fillers or excipients, sugars, or artificial sweeteners.
- Transparent labeling. Choose supplements with clear, honest labeling that lists the amount of creatine per serving and any other ingredients.
- Third-Party testing. Look to see if the brands you are interested in have third-party testing for quality and purity done for their products. Certifications like NSF Certified for Sport or Informed-Sport ensure the product is free from contaminants. NSF helps ensure the safety, quality, and transparency of dietary supplements through strict testing and certification.5
A Comparison of Creatine vs. Carbon 60 (C60) Buckminsterfullerene
|
Benefit |
Creatine |
Carbon 60 (C60) Buckminsterfullerene |
|---|---|---|
|
Cognitive Function |
May improve cognitive performance, particularly in sleep-deprived individuals.1 |
Potential neuroprotective effects that may help to support cognition.7 |
|
Cellular Health |
Supports ATP production, aiding in energy production in cells.1,5 |
Antioxidant properties that protect cells from oxidative stress.8 |
|
Recovery and Fatigue |
Reduces muscle damage and inflammation post-exercise.1,6 |
May neutralize inflammation and oxidative damage after exercise.8 |
|
Muscle Mass and Fat Loss |
Enhances muscle mass retention and fat loss through exercise.1,6 |
No direct evidence for fat loss, but may aid in overall metabolic health. |
|
Neuroprotective Effects |
Limited evidence; may support brain health in high doses.1,7 |
Strong antioxidant potential may help support the brain and nervous system. |
Key Takeaways
Creatine is a well-researched supplement that helps support performance by fueling your body’s natural energy (ATP) production, which can be beneficial for high-intensity activities. Its studied benefits also include supporting muscle mass and post-exercise recovery, along with potential cognitive support. C60 (Carbon 60) functions differently, acting as an antioxidant that helps protect cells from oxidative stress.
These two supplements can offer a complementary approach: creatine helps support energy production, while C60 helps support the body’s natural processes for dealing with oxidative stress. Whether you choose one or both, always prioritize quality. Look for pure creatine monohydrate and 99.99% pure sublimated C60 in a high-quality organic oil, ensuring both products are third-party tested for purity and concentration.
As always, before starting any new supplement regimen, it is essential to consult with your healthcare provider to discuss your personal health goals and determine what is right for you.
Disclaimer
*These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, mitigate, or prevent any disease. Individual results may vary.

Ken Swartz, MS is the co-founder, Chairman Emeritus, and former Chief Science Officer at
C60 Power, a health and wellness company committed to delivering the highest quality Carbon 60 products available.
Ken earned a Master of Science degree from the University of Colorado at Denver and a Bachelor of Science in
Economics from Arizona State University.’
References
- Kreider, Richard B et al. “International Society of Sports Nutrition position stand: safety and efficacy of creatine supplementation in exercise, sport, and medicine.” Journal of the International Society of Sports Nutrition vol. 14 18. 13 Jun. 2017, doi:10.1186/s12970-017-0173-z https://pmc.ncbi.nlm.nih.gov/articles/PMC5469049/
- Mawer, Rudy. “Everything You Need to Know about Creatine.” Healthline, Healthline Media, 25 Oct. 2018, www.healthline.com/nutrition/what-is-creatine .
- LeWine, Howard E. “What Is Creatine? Potential Benefits and Risks of This Popular Supplement.” Harvard Health, Harvard Health Publishing, 20 Mar. 2024, www.health.harvard.edu/exercise-and-fitness/what-is-creatine-potential-benefits-and-risks-of-this-popular-supplement.
- Rawson, Eric S, and Jeff S Volek. “Effects of creatine supplementation and resistance training on muscle strength and weightlifting performance.” Journal of strength and conditioning research vol. 17,4 (2003): 822-31. doi:10.1519/1533-4287(2003)017<0822:eocsar>2.0.co;2 Effects of creatine supplementation and resistance training on muscle strength and weightlifting performance – PubMed
- “Dietary Supplements and Nutritional Products.” Nsf.org, NSF, 2023, www.nsf.org/nutrition-wellness/dietary-supplements-nutritional-products .
- Wax, Benjamin et al. “Creatine for Exercise and Sports Performance, with Recovery Considerations for Healthy Populations.” Nutrients vol. 13,6 1915. 2 Jun. 2021, doi:10.3390/nu13061915. https://pmc.ncbi.nlm.nih.gov/articles/PMC8228369/
- “Should You Take Creatine to Boost Your Brain? | Psychology Today.” Www.psychologytoday.com, www.psychologytoday.com/us/blog/the-modern-brain/202311/should-you-take-creatine-to-boost-your-brain .
- Chistyakov, V A et al. “Possible mechanisms of fullerene C₆₀ antioxidant action.” BioMed research international vol. 2013 (2013): 821498. doi:10.1155/2013/821498. https://pmc.ncbi.nlm.nih.gov/articles/PMC3816026/ .